This chapter describes the potential far‐reaching consequences of contemplative higher education for the fields of science and medicine.

This article provides ethical guidance on using race in health research as a variable or in defining the study population. To this end, a plain, non-exhaustive checklist is provided for researchers and research ethics committees, preceded by a brief introduction on the need for justification when using race as a variable or in defining a study population, the problem of exoticism, that distinctions pertain between race, ethnicity and ancestry, the problematic naming of races, and that race does not serve well (...) as a presumed biological construct in genetic research. (shrink)

Much else was done by Rose and Sullivan in their possibly conclusive attempt to restore sense to the rebus passage, but the reading super scorpionem locustam was Gaselee's, as Rose and Sullivan clearly acknowledge. This seems unluckily to have escaped B. Baldwin, otherwise he would have noticed that Gaselee also fancied in his correction an allusion to the poisoner Locusta. For those who may have difficulty in obtaining Gaselee's collotype reproduction, I quote the relevant part: ‘But what have lobsters to (...) do with poisoners? Is it permissible to see a more or less open reference to Locusta, the queen of all poisoners? If so, we have here another little piece of evidence which will help us to date the Satyricon.’. (shrink)

This paper provides a retrospective and prospective overview of TU Delft’s approach to engineering ethics education. For over twenty years, the Ethics and Philosophy of Technology Section at TU Delft has been at the forefront of engineering ethics education, offering education to a wide range of engineering and design students. The approach developed at TU Delft is deeply informed by the research of the Section, which is centered around Responsible Research and Innovation, Design for Values, and Risk Ethics. These theoretical (...) approaches are premised on the notion that technologies are inherently value-laden, and as such contain the possibility of fostering or hindering moral values. Each of these approaches encourages students to take a proactive attitude with respect to their projects and profession, thinking creatively about – and taking responsibility for – how to both prevent harm and do good via the technologies they help develop. To explain how this is put into practice, this paper sketches a brief history of ethics teaching at TU Delft, outlines current activities, and presents future plans for Bachelor and Master’s level engineering ethics education at TU Delft. (shrink)

In Appearance and Reality Bradley has much to say about relations. This is to be found particularly in Chapter 3 and Appendix B, but the whole of the book is on this subject in one way or another. His views aroused immediate opposition and Bertrand Russell, among others, strongly attacked the “doctrine of internal relations,” a phrase which, be it noted, does not occur in Chapter 3 at all and makes its appearance only as part of the controversy. Russell argued (...) that some relations at least are purely external, and that if one does not grant this one is left with no option but to reject pluralism, embrace monism, and regard all truths as analytic. With characteristic honesty Russell admitted that it was aversion to these consequences which stimulated his desire to rebut opinions of the kind that Bradley held. It is the thesis of this essay that while Bradley had something important to say about the “doctrine,” he made a more important point about relations and qualities which has been overlaid by the controversy about “internal relations,” and that this point is an extremely relevant one in the context of much modern philosophizing. I will therefore attempt first of all to draw out Bradley’s most important point about relations and qualities; secondly to consider what connection this has with the “internal relations” controversy; and thirdly to decide whether Russell was right in supposing what he did about pluralism, monism, and analytic truths. (shrink)

1. The use of the imperfect τικτε ‘was the mother of’, with τíκτουσα; νίκων, ο νικντες; διδος is well known, and no doubt correctly explained. Reference is frequently made to Virgil's quem dat Sidonia Dido, but δίδου seems not to be used, no doubt because it is so extensively used in the sense of ‘offered’. In T. 7. 56. 3 περιεγíγνοντο seems to be a substitute for νíκων, ‘were victorious’; cf. φερε in Find. O. 10 , 74 ‘was prizewinner’ —the (...) other winners all have an aorist. So too Pyth. 3. 44. (shrink)

Circumstances have allowed me to inspect the Paris MSS. of Strabo and to collate them for a portion of Book IX. , in view of an edition of Strabo's Thessaly which Mr. A. J. B. Wace has in contemplation.

It will be noticed that, in the stemma above, no line of descent is marked from the first generation registered therein to the following generations. The genealogy of the Emperor Nerva is customarily traced back to the consul of 36 b.c., M. Cocceius Nerva. This short note will underline the ancient testimony found amongst the Pseudacroniana tracing his descent from the latter's brother, the consummate diplomat. There are ramifications. Amongst the items of interest will be the light shone upon what (...) Dio and Eutropius understood to be Nerva's standing at the time of his accession. Before passing on to Pseudacron's datum, it might be worthwhile pausing on that point, as well as briefly contemplating the factors that actually bore upon the emperor's ancestral training. (shrink)

The picture of L. Appuleius Saturninus' last days is usually derived from the straightforward narrative account found in Appian's Civil Wars, an account which modern analysis has shown to be flawed. That narrative may be glossed as follows. At the consular elections for the year 99, Saturninus and Glaucia instigated the death of a more hopeful contender. Chaos followed. On the following day, when the People had made its intention to do away with the ‘malefactors’ absolutely plain, Saturninus, Glaucia and (...) the quaestor Saufeius seized the Capitol with followers from the country. The Senate voted for their suppression and Marius invested the hill. With hopes of a safe conduct, the beseiged surrendered and Marius detained them in the curia. Those who feared that the seditiosi might escape rough justice broke in and killed, amongst others, ‘a quaestor, a tribune and a praetor, still decorated with the insignia of office. Many others also perished in the stasis, including another tribune, thought to be the son of Gracchus and being a tribune for the first time on that very day’: ταμίαν τε κα⋯ δήμαρχον κα⋯ στρατηγόν, ἔτι περικειμ⋯νους τ⋯ σ⋯μβολα τ⋯ς ⋯ρχ⋯ς. πολὺς δ⋯ κα⋯ ἄλλος ὅμιλος ⋯ν τῇ στάσει δι⋯φθαρτο κα⋯ δήμαρχος ἕτερος, ⋯ το⋯ Γράκχου παῖς εἶναι νομιζ⋯μενος, πρώτην δημαρχ⋯ν ⋯κε⋯νην ⋯μ⋯ραν. (shrink)

Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...) +1 transcription start site. The -219 and -491 polymorphic variations have significant association with instance of AD, and -491AA has significant risk even when stratified for the APOEepsilon4 allele. We also show significant effects on reporter gene expression in neuronal cell cultures, and, notably, these effects are modified by species origin of the cells. The -491 and -219 polymorphisms may have an interactive effect in addition to any independent activity. DNA-protein interactions differ between each polymorphic state. We propose SP1 and GATA as candidates for regulatory control of the -491 and -219 polymorphic sites. This work's significance lies in drawing connection among APOE promoter polymorphisms' associations with AD to functional promoter activity differences and specific changes in DNA-protein interactions in cell culture-based assays. Taken together, these results suggest that APOE expression levels are a risk factor for AD irrespective of APOEepsilon4 allele status. (shrink)

The essays in this volume apply philosophical analysis to address three kinds of questions: What are the implications of genetic science for our understanding of nature? What might it influence in our conception of human nature? What challenges does genetic science pose for specific issues of private conduct or public policy?

Early versions of satellite and radiosonde datasets suggested that the tropical surface had warmed more than the troposphere, while climate models consistently showed tropospheric amplification of surface warming in response to human-caused increases in greenhouse gases. We revisit such comparisons here using new observational estimates of surface and tropospheric temperature changes. We find that there is no longer a serious discrepancy between modeled and observed trends in the tropics. Our results contradict a recent claim that all simulated temperature trends in (...) the tropical troposphere are inconsistent with observations. This claim was based on the use of older radiosonde and satellite datasets and on two methodological errors: the neglect of observational trend uncertainties introduced by interannual climate variability and application of an inappropriate statistical “consistency test”.This emerging reconciliation of models and observations has two primary explanations. First, because of changes in the treatment of buoy and satellite information, new surface temperature datasets yield slightly reduced tropical warming relative to earlier versions. Second, recently developed satellite and radiosonde datasets now show larger warming of the tropical lower troposphere. In the case of a new satellite dataset from remote sensing systems, enhancedRSS warming is due to an improved procedure of adjusting for inter-satellite biases. When the RSS-derived tropospheric temperature trend is compared with four different observed estimates of surface temperature change, the surface warming is invariably amplified in the tropical troposphere, consistent with model results. Even if we use data from a second satellite dataset with smaller tropospheric warming than in remote sensing systems RSS, observed tropical lapse rates are not significantly different from those in all model simulations.Our results contradict a recent claim that all simulated temperature trends in the tropical troposphere and in tropical lapse rates are inconsistent with observations. This claim was based on the use of older radiosonde and satellite datasets and on two methodological errors: the neglect of observational trend uncertainties introduced by interannual climate variability and application of an inappropriate statistical “consistency test”. (shrink)